====== HMMER ======
Biological sequence analysis using profile hidden Markov models
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* Install
cd /root/
wget ftp://selab.janelia.org/pub/software/hmmer3/3.1b1/hmmer-3.1b1-linux-intel-x86_64.tar.gz
tar -xvzf hmmer-3.1b1-linux-intel-x86_64.tar.gz
cd hmmer-3.1b1-linux-intel-x86_64/
./configure
make
make check
make install
cd /db
wget ftp://ftp.sanger.ac.uk/pub/databases/Pfam/current_release/Pfam-A.hmm.gz
gunzip Pfam-A.hmm.gz
* Test
hmmalign -h
# hmmalign :: align sequences to a profile HMM
# HMMER 3.1b1 (May 2013); http://hmmer.org/
# Copyright (C) 2013 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Usage: hmmalign [-options]
Basic options:
-h : show brief help on version and usage
-o : output alignment to file , not stdout
Less common options:
--mapali : include alignment in file (same ali that HMM came from)
--trim : trim terminal tails of nonaligned residues from alignment
--amino : assert , both protein: no autodetection
--dna : assert , both DNA: no autodetection
--rna : assert , both RNA: no autodetection
--informat : assert is in format : no autodetection
--outformat : output alignment in format [Stockholm]
Sequence input formats include: FASTA, EMBL, GenBank, UniProt
Alignment output formats include: Stockholm, Pfam, A2M, PSIBLAST